He was regimental quartermaster at Fort Vancouver, near Portland, Oregon, for one year. In 1853 he was promoted to a captaincy and ordered to Fort Humboldt, near Eureka in California. In 1854, becoming disheartened by the never-ending vista of barrack life, and despairing of being able to have his wife and children with him, he sent in his resignation, to take effect July 31st, 1854. He had lost money by unfortunate business ventures, and so returned forlorn and penniless to New York. Thence he made his way to St. Louis to his wife and children, and began the world again as a farmer, without a house or tools or horses.

His father-in-law, Mr. Frederick Dent, who lived about ten miles out of the city, set aside some sixty or eighty acres of land for his use, and thereon he built with his own hands a log cabin, which he called "Hardscrabble." For nearly four years he lived the life of a farmer. He plowed, hoed, cleared the land, hauled wood and props to the mines, and endured all the hardships and privations of a small farmer. In 1858 his health gave way, and he moved to St. Louis in the attempt to get into some less taxing occupation. He tried for the position of county engineer, and failed. He went into the real estate business with a friend, and failed in that. He secured a place in the customs office, but the collector died and he was thrown out of employment.

In the spring of 1860, despairing of getting a foothold in St. Louis, he removed to Galena, Illinois, where his father had established a leather store, a branch of his tannery in Covington, Kentucky. Here he came in touch again with his two brothers, Simpson and Orvil Grant. He became a clerk at a salary of six hundred dollars per annum. At this time he was a quiet man of middle age, and his manner and mode of life attracted little attention till in 1861, when Sumter was fired upon and Lincoln called for volunteers. Galena at once held a war meeting to raise a company. Captain Grant, because of his military experience, was made president of the meeting, and afterward was offered the captaincy of the company, which he refused, saying, "I have been a captain in the regular army. I am fitted to command a regiment."

He wrote at once a patriotic letter to his father-in-law, wherein he said, "I foresee the doom of slavery." He accompanied the company to Springfield, where his military experience was needed. Governor Richard Yates gave him work in the adjutant's office, then made him drill-master at Camp Yates; and as his efficiency became apparent he was appointed governor's aide, with rank of colonel. He mustered in several regiments, among them the 7th Congressional regiment at Mattoon. He made such an impression on this regiment that they named their camp in his honor, and about the middle of June sent a delegation of officers to ask that he be made colonel. Governor Yates reluctantly appointed him, and at the request of General John C. Frémont, the commander of the Department of the West, Grant's regiment (known as the 21st Illinois Volunteers) was ordered to Missouri. Colonel Grant marched his men overland, being the first commander of the State to decline railway transportation. His efficiency soon appeared, and he was given the command of all the troops in and about Mexico, Missouri. At this point he received a dispatch from E. B. Washburne, Congressman for his district, that President Lincoln had made him brigadier-general. He was put in command at Ironton, Missouri, and was proceeding against Colonel Hardee, when he was relieved from command by B. M. Prentiss and ordered to Jefferson City, Missouri. He again brought order out of chaos, and was ready for a campaign, when he was again relieved, and by suggestion of President Lincoln placed in command of a district with headquarters at Cairo, Illinois.

This was his first adequate command, and with clear and orderly activity he organized his command of nearly ten thousand men. On the 6th of September, learning that the Confederates were advancing on Paducah, he took the city without firing a gun, and issued an address to the people of Kentucky which led Lincoln to say, "The man who can write like that is fitted to command in the West." Early in November, in obedience to a command from Frémont, he fought the battle of Belmont, thus preventing General Polk from reinforcing Price in Missouri. This was neither a victory nor a defeat, as the purpose was not to hold Belmont.

In February 1862, with an army of twenty thousand men and accompanied by Commander Foote's flotilla, he took Fort Henry and marched on Fort Donelson. On the 16th of the same month he had invested Donelson and had beaten the enemy within their works. General Simon Buckner, his old classmate and comrade, was in command. He wrote to Grant, asking for commissioners to agree upon terms. Grant replied: "No terms except an unconditional and immediate surrender can be accepted. I propose to move immediately upon your works." Buckner surrendered, and Grant's sturdy words flamed over the land, making him "Unconditional Surrender Grant." The whole nation thrilled with the surprise and joy of this capture, and the obscure brigadier-general became the hero of the day. He was made major-general, and given the command of the District of Western Tennessee.

On the 6th and 7th of April he fought the terrible battle of Shiloh, and won it, though with great loss, owing to the failure of part of his reinforcements to arrive. Immediately after this battle, General H. W. Halleck, who had relieved General Frémont as commander in the West, took command in person, and by a clever military device deprived Grant of all command; and for six weeks the army timidly advanced on Corinth. Corinth was evacuated by the enemy before Halleck dared to attack, and Grant had no hand in any important command until late in the year.

Halleck went to Washington in July, leaving Grant again in command; but his forces were so depleted that he could do little but defend his lines and stores. In January 1863 he began to assemble his troops to attack Vicksburg, but high water kept him inactive till the following April. His plan, then fully developed, was to run the battery with gunboats and transports, march his troops across the peninsula before the city, and flank the enemy from below. This superbly audacious plan involved cutting loose from his base of supplies and all communications. He was obliged to whip two armies in detail,—Johnston at Jackson, Mississippi, and Pemberton in command at Vicksburg. This marvelous campaign was executed to the letter, and on the third day of July, Pemberton surrendered the largest body of troops ever captured on this continent up to that time, and Grant became the "man of destiny" of the army. All criticism was silenced. The world's markets rose and fell with his daily doings. Lincoln wrote him a letter of congratulation. The question of making "the prop-hauler of the Gravois" general-in-chief of all the armies of the United States was raised, and all the nation turned to him as the savior of the republic.

He was made commander of all the armies of the Mississippi, and proceeded to Chattanooga to rescue Rosecrans and his beleaguered army. In a series of swift and dramatic battles he captured Lookout Mountain and Missionary Ridge. Wherever he went, victory seemed to follow. His calm demeanor never changed. He was bent on "whipping out the Rebellion." He was seen to be a warrior of a new sort. He was never malignant, or cruel, or ungenerous to his enemies; but he fought battles to win them, and the country now clamored for him to lead the armies of the Potomac against Lee, the great Southern general against whom no Northern general seemed able to prevail.

Early in March of 1864, Hon. E. B. Washburne introduced into Congress a bill reviving the grade of Lieutenant-General. It was passed by both houses with some discussion, and Lincoln conferred the title and all it implied upon Grant. He called him to Washington, and placed the whole conduct of the war in his hands. "I don't want to know your plans," he said. Grant became absolutely chief in command, and set forth at once to direct the Army of the Potomac in person, and to encompass Lee as he had captured the armies of Buckner and Pemberton. His aim was not to whip Lee, but to destroy his army and end the war. He began an enormous encircling movement which never for one moment relaxed. The Army of the Potomac retreated no more. It had a commander who never knew when he was beaten.