Case I.—W. T., aged twenty-five. Failure of vision extending over two years, with reduction of visual acuity to the power of counting fingers at three feet. Double optic atrophy; pupils medium, with distinct light response; knee-jerks distinct and no evidence of spinal disease, and no cerebral symptoms other than one or two attacks of giddiness. Urethritis, but no syphilis.
Case II.—F. R., aged thirty-eight. Double optic atrophy, with almost complete loss of vision, the defective sight having been observed for at least eighteen months; pupils dilated and immobile; no evidence of spinal disease, unless possibly some degree of failure of sexual power; no cerebral incidents; no history or evidence of syphilis.
(b) Optic Atrophy, with Other Ocular Evidence Suggestive of Locomotor Ataxy.
Case III.—(By permission of Mr. Ernest Clarke, F. R. C. S.) R. C., aged thirty-nine. Double optic atrophy, reducing right visual acuity to the power to count fingers at four feet, and left to mere perception of light; right pupil dilated and three times the size of the left; neither any light response, but free movement on convergence; entire absence of symptoms and objective signs of spinal disease; “gleet” twenty years before, no syphilis.
Case IV.—A. S., aged twenty-five. Double optic atrophy, with observed failure of vision for twelve months. V. A. right-hand movements only; left, 6
18 part; pupils 2.5 mm., no light response, but contract on convergence; knee-jerks difficult to obtain, but movement, though possibly wanting in promptness, is normal in extent; no ataxia or other evidence of spinal disease; mother of three healthy children, no miscarriages.
(c) Optic Atrophy, with Some Evidence of Spinal Disease.
Case V.—W. A., aged thirty-seven. Double optic atrophy, with reduction of visual acuteness to “hand movements;” pupils dilated and immobile; knee-jerks absent, but no other evidence of spinal disease; venereal sore when aged twenty; no recognized secondaries, and father of four healthy children.
Case VI.—J. G., aged thirty-five. Failure of sight (six months); optic atrophy, gradually increasing whilst under observation of twelve months; pupils not definitely abnormal; knee-jerks absent throughout, but no further appearance of spinal disturbance; urethritis, but no history of syphilis; father of two healthy children, wife no miscarriages.
Case VII.—F. L., aged thirty-nine. Double optic atrophy, reducing visual acuteness to 6
24, pupils very small, and with Argyll-Robertson phenomenon; subsequent to failure of sight (twelve months) has had shooting pains in thighs, and failure in retention power of bladder; knee-jerks distinct; no ataxia or sensory defect in lower limbs; venereal sore twenty years before; no recognized secondary syphilis; wife healthy: seven pregnancies, five miscarriages.