19 November. The mixture was applied to 2 sq. cm. of skin. After 30 seconds it was ignited and after burning for 40 seconds it was wiped off with R 17. A dry burn appeared. During the following days a small oedematous swelling developed. The wound was treated with liquid echinacine. Thereafter, the swelling subsided rapidly, so that on 1 December there remained a clear, dry wound without necrosis. Subsequently to this a broad zone of epithelization formed and by 29 December the wound had healed with the exception of 0.5 sq. cm. still lacking epithelium.
19 November. The mixture was again applied to 2 sq. cm. of skin, ignited after 30 seconds, but treated with R 17 only after burning 60 seconds. Here too a dry burn appeared, however with severe reddening and pain in the surrounding area. The wound formed a necrotic coating. On the third day it was treated with a 10 percent solution of cod-liver-oil ointment. On 19 December it was circumscribed and dry. A slow epithelization began. Later the wounded skin area became similar to the smooth surrounding area. On 29 December the wound had not yet healed over.
c. Application to a piece of cloth covering the skin.
25 November. The phosphorus-caoutchouc mixture, applied to a piece of cloth covering the skin was ignited. Sixty-seven seconds elapsed before it had burned itself out. The piece of cloth, except for a small remainder, was carbonized. After it was wiped off with R 17 there appeared on skin a burn with a central blister which later developed to a thin, elastic scab. After 3 days the wound was treated with echinacine ointment. Until 3 December cleaning of the wound took place; at this date it was dry, rosy red, and closed; a fine granulation covered it. Thereupon rapid epithelization began. On 29 December it was not yet healed over.
2. With CuSO4.
a. Immediate ignition.
25 November. The mixture was applied to a skin area of 6 × 3 cm., and immediately ignited. After burning 20 seconds it was extinguished with water, and then wiped off with copper-sulphate solution. During this operation the entire epidermis separated from the area of the wound. An oedematous swelling of the surrounding area, 12 × 13 cm. in extent and a thick scab formed. Treatment took place with liquid echinacine. On 7 December the necrosis began to slough off, and gradual epithelization took place. On 21 December one-third of the area of the wound was still without epithelium (cf. II/1/a/aa). On 29 December the wound was healed over.
25 November. The mixture was again applied to a skin area of 6 × 3 cm. and immediately ignited. After it had burned itself out in 60 seconds, the burned area was wiped off with copper-sulphate solution. A brownish-grey burn with thickening of the skin appeared. The thickening developed to a strong scab. It was treated with a 10-percent solution of cod-liver oil ointment. The surrounding area remained very red and painful. On 10 December a subcutaneous suppuration appeared at the edge of the wound. Consequently the treatment with cod-liver oil was replaced by liquid echinacine. On 13 December the scab separated from the greater part of the wound, but the surrounding area remained more inflamed than in the corresponding experiment with R 17 (cf. II/1/a/bb). The granulation was coarse and uneven. On 29 December the wound was not yet healed over; epithelization advanced only slowly.
b. Ignition after 30 seconds.
19 November. The phosphorus-caoutchouc mixture was applied to 2 sq. cm. of skin and left there for 30 seconds; then it was ignited and after burning for 60 seconds wiped off with copper-sulphate solution. A brownish-black viscous mass formed; the dry wound discolored to a blackish-grey. Thereupon a thick crust formed and a considerable oedematous swelling of the area surrounding the wound developed. Treatment took place with echinacine ointment. The swelling subsided more slowly than in the treatment with R 17 (cf. II/1/b/aa). On 5 December the wound was without necrosis, with a wide zone of epithelization. On 29 December it had healed over except for 1 sq. cm. lacking in epithelium (cf. II/1/bb/aa).