| Report After the Original No. 33 | |
| Author: Goldberger, Joseph (USA Public Health Service 1914). | |
| Quoted from: Bernhard Jaffe, Scientists in America, Overseas Edition Incorporated, New York 1944, page 401 et seq. | |
| Purpose: Proof that pellagra is a deficiency disease. | |
| Experiment: One-sided deficiency diet (restricted in quality) which caused 7 severe cases of pellagra. | |
| Experimental persons: 12 voluntary prisoners of the Rankin-Prison-Farm to whom their freedom was promised after survival of the experiment, with the agreement of the governor of the state. All survived and were set free. | |
| Excerpt from Original 44 | |
| Author: Fraenkel, E. | |
| Title: Report on Infectious Colpitis Epidemica Observed in Children. | |
| Quoted from: Arch. Path. Anath. a. Physiol. (Virchow) 99, 251 (1885). | |
| Purpose: Page 263: Confirmation of the suspicion of an “infection of the conjunctiva caused by vaginal secretion.” Animal tests showed negative results. | |
| Experiment: Page 263: “By chance I had the possibility to inoculate the vaginal secretion (of sick women) into the conjunctiva of 3 children patients who were in the final stage of the disease (two were suffering from atrophia infantum, the third from cheesy pneumonia) * * *.” | |
| Page 264: “The two pus-producing patients had suffered for several weeks from their colpitis.” | |
| Result: 2 children died—1½ and 2 days after the inoculation without showing any reactions. The third child contracted conjunctivitis, which healed after treatment, and died on the 10th day. | |
| Experimental subjects: 3 moribund children. | |
| Excerpt from Original 48 | |
| Author: Current Comment. Summary of a study taken from Epidemiology Unit No. 50. | |
| Title: Cholera Studies in Calcutta. | |
| Quotation: Journal of the American Medical Association 130, 790 (1946). | |
| Aim: Page 790: “* * * control experiment on the treatment of cholera * * *.” | |
| Experiment: Page 790: “* * * in a highly endemic or epidemic area of India, patients were taken in rotation as they were admitted to the hospital and assigned to the following group according to the treatment given: | |
| A, sulfaguanidine; | |
| B, control; | |
| C, sulfadiacine; | |
| D, penicillin; and | |
| E, sulfadiacine and penicillin combined. | |
| All patients received supportive treatment in the form of i.v. hypertonic and isotonic solution of sodium chloride and oral stimulants as indicated of offset dehydration, emaciation, and circulatory failure.” | |
| Result: Page 791: | |
| 1. Patient treated with plasma in addition to chemo-therapy: death rate: zero. | |
| 2. Patients receiving chemo-therapy alone: death rate 1.1 percent. | |
| 3. Control group consisting of all patients who had not received treatment or who had insufficient treatment or only supportive treatment: death rate 38.3 percent. | |
| “The dramatic effect of plasma is still more evident if the shock or collapse cases are segregated and tabulated. There were, in all, 78 severely ill patients in that group. The results in the group showed a mortality rate of 95.8 percent for the control group, 15.8 percent for the chemo-therapy, and no mortality in the group treated with plasma plus chemo-therapy.” | |
| Experimental subjects: | |
| No numbers given, presumably several hundred, nonvoluntary as clinical serial tests. | |
PARTIAL TRANSLATION OF DOCUMENT KARL BRANDT 117
KARL BRANDT DEFENSE EXHIBIT 103
EXCERPTS FROM THE DISSERTATION “INFECTION EXPERIMENTS ON HUMAN BEINGS” BY ALFRED HEILBRUNN OF THE HYGIENE INSTITUTE OF THE WUERZBURG UNIVERSITY, 1937, CONCERNING EXPERIMENTS ON HUMAN BEINGS IN OTHER COUNTRIES
Excerpt from “Infection Experiment on Human Beings”
Inaugural Dissertation for the Attainment of the Degree of a Doctor of Medicine at the Friedrich-Wilhelm University of Berlin;
submitted by: Alfred Heilbrunn,
Hofgeismar (Hesse Nassau) 1937