June 30: 1.75 grams caffein administered.
July 2: Dog weighed 13.5 kilos; 2 grams caffein or 0.15 gram per kilo, caused well-marked thirst, but did not produce any other symptoms.
Dog 20. Female.
May 12: Weight, 7.7 kilos. Fed liberal carbohydrate diet, consisting of rice, 100 grams; sugar 100 grams; meat and cracker meal, a sufficient quantity to flavor the food.
May 14: Weight, 7.7 kilos. Examination of urine for albumin and sugar gave negative results. Urine was acid to litmus.
May 17: Weight, 7.4 kilos. Three hours after it was fed the dog received 0.5 gram caffein by mouth. The test of the urine the next day for sugar was negative, but a trace of albumin was present. It will be noticed that the doses were increased gradually and that symptoms were observed only after the fourth dose of 0.1 gram per kilo. Later meat was substituted for the carbohydrate diet and the administration of caffein was stopped for four days. At the end of this period 100 mg caffein per kilo was fed daily for five days, and the dose was then very gradually increased. Diarrhea occurred twice, but no other symptoms, the second attack having lasted a few days. The following is a complete record of the experiment:
May 19: 0.5 gram caffein 11.45 a. m.
May 20: 0.75 gram caffein 12.45 a. m.
May 21: 0.75 gram caffein 12 noon; no sugar, no albumin in urine.
May 22: 0.75 gram caffein; urine, same condition found; no symptoms.