November 20: Urine examined, no sugar found, no symptom noticed at any time after injection.
Rabbit 254. Belgian hare, female. Weight, 975 grams. Diet, oats.
November 19: 4.05 p. m., 18 cc 2 per cent caffein (369 mg per kilo) administered by mouth, followed by 10 cc of 0.9 per cent salt solution.
November 20: 9 a. m., rabbit found dead.
Rabbit 267. White. Weight, 1,050 grams. Diet, oats.
November 23: 12.10 p. m., 18 cc 2 per cent caffein (342 mg per kilo) given by mouth, followed by 18 cc salt solution; 1 p. m., increased reflexes, tremors marked but no tetanus; 1.05 p. m., rabbit stretched on abdomen, posterior extremities in extended position and paralyzed, soon after clonic spasms set in, which recurred about every minute; 1.14 p. m., tetanus and death. Autopsy: Liver showed fatty degeneration; slight inflammation of stomach and intestines; other organs normal.
Rabbit 268. White. Weight 1,100 grams. Diet, oats.
November 23: 20 cc 2 per cent caffein (363 mg per kilo) administered by mouth, followed by 20 cc salt solution; 1.15 p. m., somewhat hypersensitive; 4.30 p. m., tremors fairly marked, no urine passed, about 2 cc of bloody looking urine obtained from bladder, which contained albumen and a considerable amount of glycogen; rabbit died.
Rabbit 419, Belgian hare, male. Weight, 1,600 grams. Diet, oats.
September 26: 10 a. m., 28 cc 2 per cent caffein (350 mg per kilo) given by mouth; reflexes increased at 4 p. m.; 6 p. m., reflexes still increased, no other symptoms.