October 3: 2.25 p. m., 3.5 cc 2 per cent caffein (0.219 gram per kilo) injected subcutaneously in the back; 3.40 p. m., convulsion with recovery; 3.50 p. m., frequent spasms with paralysis, especially of anterior extremities; 5.30 p. m., tetanus when removed from cage and put on floor.
October 4: 8.50 a. m., found dead. Autopsy: Congestion of small intestines, lungs, liver.
Guinea pig 57. White and gray female. Weight, 350 grams. Diet, oats.
October 3: 2.15 p. m., 3.5 cc 2 per cent caffein injected subcutaneously in the back (0.2 gram per kilo); 3.40 p. m., convulsions with recovery; 5.30 p. m., no marked symptoms.
October 4: 8.50 a. m., alive, active.
October 6: Found dead at 9 a. m. Autopsy: Congestion of lungs and liver; kidneys petechiated; severe gastro-enteritis.
Guinea pig 68. Yellow male. Weight, 785 grams. Diet, oats.
October 6: 11.35 a. m., 7.8 cc 2 per cent caffein (0.2 gram per kilo) injected subcutaneously; 12 noon, reflexes increased markedly; 4.20 p. m., reflexes the same as at 12 noon.
October 7: 9 a. m., dead. Autopsy: Lungs congested; liver congested and fatty; spleen congested, kidney showed hemorrhagic spots; gastric mucosa necrotic; small portion of small intestine inflamed.
Guinea pig 69. White male. Weight, 585 grams. Diet, oats.