Guinea pig 134. White and brown male. Weight, 740 grams. Diet, hay and oats.
June 9: 2.55 p. m., 6 cc warm 2 per cent caffein solution given by mouth through stomach tube; 4.50 p. m., reflexes increased.
June 10: 9.30 a. m., reflexes much less than day before, increase slight, a few cubic centimeters of urine passed since injection of caffein, looked brown and dirty, could not be tested for reducing substances.
June 13: Guinea pig alive, appetite good, condition good.
June 14: 9 a. m., found dead.
Guinea pig 128. White and black male. Weight, 1,075 grams. Diet, hay and oats.
June 7: 10 a. m., 11 cc 2 per cent caffein by mouth through stomach tube; 11.10 a. m., no symptoms, no urine passed; 1 p. m., increased reflexes, about 15 cc (estimated) urine passed; 4 p. m., reflexes increased, still more urine passed (about 20 cc); 4.50 p. m., tetanus, frequent attacks, then paralysis and death at 4.58 p. m. Autopsy: Lungs congested; blood vessels of heart injected; intestines slightly congested; fatty liver.
Guinea pig 126. White and gray male. Weight, 980 grams. Diet, oats and hay.
June 7: 9.40 a. m., 9.8 cc 2 per cent caffein given by mouth through stomach tube; 10 a. m., no symptoms; 11.10 a. m., no urine passed, reflexes increased; 1 p. m., more sensitive than before; 4 p. m., increase of reflexes more marked, no urine passed; 4.45 p. m., about 15 cc urine collected; 5 p. m., no change.