Loewenstein and Kaufmann's Scheme: Repetition of small dose, relying on exciting hypersensibility—2⁄10 mg.; in 3 days, 2⁄10 mg.; in 3 days, 2⁄10 mg.; in 3 days, 2⁄10 mg.
Some use 1⁄10 mg., or 3⁄4, or 11⁄4, in same way.
This scheme is based on hypersensibility created by repetition of same dose in tuberculous subjects. Scheme not used at present.
Some advise single dose: 3 or 5 mg., (on the ground that gradual increase of doses creates tolerance).
7. Rules to Follow in Increasing Dose:
a If no reaction with one dose, give a larger one next time, according to b.
b If temperature rises less than 1 degree F, repeat same dose; otherwise increase.
c Avoid large doses in cases of weakness, nervous temperament, children, etc. In a majority of cases smaller doses suffice.
8. After Injection: