But in nothing is this nice action of the extremities of the blood-vessels so wonderful, as in the production of contagious matter. A small drop of variolous contagion diffused in the blood, or perhaps only by being inserted beneath the cuticle, after a time, (as about a quarter of a lunation,) excites the extreme vessels of the skin into certain motions, which produce a similar contagious material, filling with it a thousand pustules. So that by irritation, or by sensation in consequence of irritation, or by association of motions, a material is formed by the extremities of certain cutaneous vessels, exactly similar to the stimulating material, which caused the irritation, or consequent sensation, or association.

Many glands of the body have their motions, and in consequence their secreted fluids, affected by pleasurable or painful ideas, since they are in many instances influenced by sensitive associations, as well as by the irritations of the particles of the passing blood. Thus the idea of meat, excited in the minds of hungry dogs, by their sense of vision, or of smell, increases the discharge of saliva, both in quantity and viscidity; as is seen in its hanging down in threads from their mouths, as they stand round a dinner-table. The sensations of pleasure, or of pain, of peculiar kinds, excite in the same manner a great discharge of tears; which appear also to be more saline at the time of their secretion, from their inflaming the eyes and eye-lids. The paleness from fear, and the blush of shame, and of joy, are other instances of the effects of painful, or pleasurable sensations, on the extremities of the arterial system.

It is probable, that the pleasurable sensation excited in the stomach by food, as well as its irritation, contributes to excite into action the gastric glands, and to produce a greater secretion of their fluids. The same probably occurs in the secretion of bile; that is, that the pleasurable sensation excited in the stomach, affects this secretion by sensitive association, as well as by irritative association.

And lastly it would seem, that all the glands in the body have their secreted fluids affected, in quantity and quality, by the pleasurable or painful sensations, which produce or accompany those secretions. And that the pleasurable sensations arising from these secretions may constitute the unnamed pleasure of exigence, which is contrary to what is meant by tedium vitæ, or ennui; and by which we sometimes feel ourselves happy, without being able to ascribe it to any mental cause, as after an agreeable meal, or in the beginning of intoxication.

Now it would appear, that no secretion or excretion of fluid is attended with so much agreeable sensation, as that of the semen; and it would thence follow, that the glands, which perform this secretion, are more likely to be much affected by their catenations with pleasurable sensations. This circumstance is certain, that much more of this fluid is produced in a given time, when the object of its exclusion is agreeable to the mind.

[2]. A forceable argument, which shews the necessity of pleasurable sensation to copulation, is, that the act cannot be performed without it; it is easily interrupted by the pain of fear or bashfulness; and no efforts of volition or of irritation can effect this process, except such as induce pleasurable ideas or sensations. See Sect. [XXXIII. 1. 1].

A curious analogical circumstance attending hermaphrodite insects, as snails and worms, still further illustrates this theory; if the snail or worm could have impregnated itself, there might have been a saving of a large male apparatus; but as this is not so ordered by nature, but each snail and worm reciprocally receives and gives impregnation, it appears, that a pleasurable excitation seems also to have been required.

This wonderful circumstance of many insects being hermaphrodites, and at the same time not having power to impregnate themselves, is attended to by Dr. Lister, in his Exercitationes Anatom. de Limacibus, p. 145; who, amongst many other final causes, which he adduces to account for it, adds, ut tam tristibus et frigidis animalibus majori cum voluptate perficiatur venus.

There is, however, another final cause, to which this circumstance may be imputed: it was observed above, that vegetable buds and bulbs, which are produced without a mother, are always exact resemblances of their parent; as appears in grafting fruit-trees, and in the flower-buds of the dioiceous plants, which are always of the same sex on the same tree; hence those hermaphrodite insects, if they could have produced young without a mother, would not have been, capable of that change or improvement, which is seen in all other animals, and in those vegetables, which are procreated by the male embryon received and nourished by the female. And it is hence probable, that if vegetables could only have been produced by buds and bulbs, and not by sexual generation, that there would not at this time have existed one thousandth part of their present number of species; which have probably been originally mule-productions; nor could any kind of improvement or change have happened to them, except by the difference of soil or climate.

[3]. I conclude, that the imagination of the male at the time of copulation, or at the time of the secretion of the semen, may so affect this secretion by irritative or sensitive association, as described in No. [5. 1]. of this section, as to cause the production of similarity of form and of features, with the distinction of sex; as the motions of the chissel of the turner imitate or correspond with those of the ideas of the artist. It is not here to be understood, that the first living fibre, which is to form an animal, is produced with any similarity of form to the future animal; but with propensities, or appetences, which shall produce by accretion of parts the similarity of form, feature, or sex, corresponding to the imagination of the father.