Case 29 took place in the Manchester Royal Infirmary, on December 24th, 1852, during the removal of a malignant tumour of the thigh, by Mr. Jordan. The patient was Henry Hollingsworth, a factory operative. His age is not stated. “The man was very much excited, struggled and talked fast. The chloroform was administered slowly, and every precaution was taken to prevent any danger, and the medical men remarked two or three times how very long it was in taking effect. He at last became insensible, in about seven minutes at least. Mr. Jordan commenced the operation by an incision into the skin covering the tumour. I was assisting the surgeon when Mr. Heath directed my attention to the patient’s face. This was about five minutes after the operation had commenced. I then observed congestion about the face, but there was no stertorous breathing. His pupils appeared almost to have ceased to act. His breathing was becoming exceedingly slow, and he seemed to be sinking fast. I directed the attention of the operator and the other medical men to these symptoms. The operation was then suspended, and means were resorted to for restoring animation, but the pupils had ceased to act, and had become fixed almost immediately. He gave one strong gasp, and then to all appearance was dead. In administering the chloroform, successive doses were given until it took effect. Every dose consisted of a drachm, taken, at intervals, in an inhaler.”[[98]]
The following remark is made respecting the autopsy. “The post-mortem examination shewed that asphyxia, caused by chloroform, produced the death. There was a congestion both of the brain and lungs.” The appearances met with after death from chloroform do not indicate the way in which death has taken place. In animals that are killed by it, the right cavities of the heart are always found filled with blood, whether they die suddenly by its direct action on the heart, or more slowly by its effects on the brain, and the breathing ceases before the circulation. The lungs are seldom much congested in animals, whichever be the mode of dying, and the appearances in the head are not unusual. The state of the pulse is not mentioned in the above account of the case; but congestion about the face was first observed, and then it was noticed that the breathing was getting slow. It is sufficiently probable that the breathing ceased on account of the action of the heart being first arrested; but even if the respiration was embarrassed by the action of the chloroform on the brain, it is pretty certain that that agent also acted directly on the heart; for it cannot be supposed that the means used for restoring animation would have failed, if the heart had been acting properly when the breathing ceased.
Case 30 took place on March 19th, 1853, in University College Hospital, London. The subject of it was an unmarried woman, named Caroline Baker, aged twenty-eight. The chloroform was administered with the intention of applying nitric acid to a sloughing ulceration of the labia and vagina. “The chloroform, supposed in the first instance to be about a drachm, was poured on lint about five inches square, and folded four or five times over. After a short time the patient became restless, talked loudly, and threw about her arms. Soon afterwards a partial relaxation of the limbs took place, and she became insensible and pulseless.”[[99]]
Further symptoms are not given, but it is stated that she sank and died. The breathing is not mentioned, but Mr. Erichsen, who, although not present at the accident to his patient, would be made aware of all that occurred, stated at the inquest, that death was produced by a paralysis of the heart from the influence of the chloroform. Dr. Quain examined the structure of the heart with the microscope, and he “found that organ, particularly on the right side, in a state of fatty degeneration.”
Case 31 was communicated to the Society of Surgery of Paris by M. De Vallet, Surgeon-in-chief to the Hôtel-Dieu, d’Orléans. “A soldier of the line, aged twenty-five, apparently in good health, and of strong frame, consulted M. Vallet for a small tumour situated behind the right labial commissure. Before operating, he proceeded to direct the inhalation of chloroform. The patient, fasting, being placed in the horizontal posture, the chloroform (about one gramme) was poured upon a hollow sponge, and applied to the nose, the mouth being left free. At the expiration of a minute, no effect having been produced, four grammes were poured on the sponge, and at the expiration of four minutes, the patient, without having experienced any irritation of the larynx, without having manifested any resistance, without redness of the countenance, and after only a slight period of agitation, fell into a state of insensibility fit for the operation. Scarcely had the incision been made, necessary to expose the cyst, when the patient became pale, respiration was suspended, and he sank into a state of complete collapse. All the usual remedies were tried, and without avail. M. Vallet opened the trachea, and performed artificial respiration with an elastic tube; then an electric current was sent by needles through the region of the heart. The patient died without any sign of reaction.
“Examination of the body.—The vessels of the brain were empty; the lungs were congested with blood, which in some situations was extravasated; the heart was excessively flaccid; there were some soft clots in the right cavities; the left were empty. The stomach was full of gas; the liver, spleen, and kidneys were gorged with black blood.”[[100]]
Case 32 occurred in the Royal Infirmary of Edinburgh to a man aged forty-three, on whom Dr. Dunsmure was about to operate for stricture of the urethra by perineal section. The chloroform was administered by Dr. Struthers. About an ounce of chloroform was used, and the patient had been put under the influence of this agent on two former occasions, when a similar quantity was employed without ill effect. The following is Dr. Dunsmure’s account of the case:—
“While the patient was inhaling the drug, he struggled considerably, and became a good deal congested in the face and head. He seemed to take a slight convulsion, like an epileptic fit, and such as I have seen on several occasions in people who have led an intemperate life. During the convulsion, the handkerchief containing the chloroform was removed to some distance from the face. In a short time the inhalation took effect, and he began to snore, and although still violent, the chloroform was removed from the face entirely, and the handkerchief placed under the pillow. As soon as the patient became more quiet, he was pulled down on the table, and placed in the proper position for the operation. I then shaved the perineum, and was just going to make my first incision, when one of the assistants said that his pulse was becoming weak. The posterior tibial, Mr. Spence then remarked, was good, but in a second or two after, both gentlemen exclaimed that the pulse was gone. I rushed from my seat to the patient’s head, and found that his breathing had ceased. Those present who had an opportunity of observing the respiration, which I had not, owing to the stool on which I sat being low, positively assert that the breathing did not cease before the pulse. The face was much congested, the jaws were firmly closed, and the pupils were dilated. I immediately forced open the lower jaw by means of the handle of a staff, and with catch forceps pulled out the tongue. Artificial respiration was had recourse to, and in a few minutes he made a long inspiration. This was soon followed by a second, by a third at a longer interval, by a fourth at a still longer period, and then by a fifth, when all attempts at natural breathing ceased. No pulsation could be felt in the radial arteries. The chest was noticed to be much contracted, to have apparently lost its elasticity, and not to expand when the ribs were forcibly compressed during the artificial respiration. I had previously sent for a galvanic apparatus, which was in the flat below, and it arrived almost immediately after the patient had made the fifth inspiration. When the tongue was pulled out, and before the first breath was taken, I was on the point of opening the trachea, but this proceeding was then abandoned; it was now, however, had recourse to, in order to carry on artificial respiration more certainly: the external jugular was also opened, and about a couple of ounces of blood flowed. By the time the tracheotomy tube was inserted, the galvanic apparatus was in working condition, and it was applied on each side of the diaphragm. It acted remarkably well; at each application of the sponges, the muscle descended as if the patient was in life; air passed through the tube in the trachea, and for some time I was in great hopes that the man was to be saved; but the muscle gradually lost its contractility, and although the galvanism was kept up for an hour, it was evident that all our efforts were in vain—that life was extinct. The post-mortem examination was made the following day at one o’clock, rather more than twenty-four hours after the patient’s death, and I give the report of it as drawn up by Dr. Gairdner, the pathologist to the Infirmary:—
“John Mitchell, aged forty-three, died 28th September. A very robust man; height five feet eight inches; diameter (lateral) of base of thorax, ten and a half inches.
“External appearances.—Considerable lividity of face and neck, and more than usual congestion of depending parts. Considerable amount of fat, but more in omentum and around viscera of abdomen than in external parietes.