Serhii (Sergei) Ivanovich Rudenko was a prominent Ukrainian Soviet anthropologist and archaeologist who discovered and excavated the most celebrated of Scythian burials, Pazyryk in Siberia.

Sergei Ignatevich Rudenko was a Soviet Marshal of the aviation.

Sergei Ryabov is a Russian film director, artist, and animator.

Sergei Sergeyevich Oldenburg was a bureaucrat and biographer from Imperial Russia. He wrote a comprehensive account of Tsar Nicholas II of Russia and his reign from an apologetic, conservative amd monarchist perspective.

Sergei Sergeyevich Shchegléiev was a Russian botanist, Ph.D. in botany, and associate professor at the Department of Botany at the National University of Kharkiv.

Sergei Nikolayevich Sergeyev-Tsensky was a prolific Russian and Soviet writer and academician. According to the opinion of Sergei Sossinsky, although "Sergeyev-Tsensky does not belong to Russia's top classical authors, he might have [been] if he had not had the misfortune of living half his life under Communist rule."

Sergei Matveevich Shtemenko was a Soviet general who served as the Chief of the Soviet Armed Forces' General Staff from 1948 to 1952.

Sergei Mikhailovich Slonimsky was a Russian and Soviet composer, pianist and musicologist.

Father Sergei Mikhailovich Solovyov was a Russian Symbolist poet, religious philosopher and an Orthodox priest. Solovyov was a grandson of the historian Sergey Solovyov, a nephew of the poet and philosopher Vladimir Solovyov, second cousin of Alexander Blok, and a friend of Andrei Bely.

Sergei Alexandrovich Solovyov was a Soviet and Russian film director, producer, screenwriter, and actor. In 1993 he was awarded the People's Artist of Russia title.