Sergey Aleksandrovich Trakhimenok, is a Belarusian writer who publishes in the Russian language. He is also a screenwriter, Doctor of Law, professor, secretary of the Belarusian Writers' Union, and a member of the Union of Russian Writers.

Count Sergey Semionovich Uvarov was an Imperial Russian classical scholar, best remembered as an influential imperial statesman under Nicholas I of Russia.

Sergey Ivanovich Vavilov was a Soviet physicist, the President of the Academy of Sciences of the Soviet Union from July 1945 until his death. His elder brother Nikolai Vavilov was a famous Russian geneticist.

Sergey Vasilyevich Vikulov was a Soviet and Russian poet, editor, and the Union of Soviet Writers' official.

Prince Sergei Grigorievich Volkonsky was a Russian Empire Major General and Decembrist from the aristocratic Volkonsky family.

Sergey Vsevolodovich Yablonsky was a Soviet and Russian mathematician, one of the founders of the Soviet school of mathematical cybernetics and discrete mathematics. He is the author of a number of classic results on synthesis, reliability, and classification of control systems, the term used in the USSR and Russia for a generalization of finite state automata, Boolean circuits and multi-valued logic circuits.

Sergey Andreyevich Yuriev was a Russian journalist, editor, publisher, translator, theatre critic and essayist, associated with the Slavophile circles.

Sergey Yustinovich Bagotsky was a Russian Marxist revolutionary and Soviet medicine and Red Cross diplomat, Soviet head of the Red Cross representative mission to Geneva from 1918 to 1936.

Sergey Zagraevsky was a Russian-Israeli painter, architectural historian, writer and theologian.

Sergey Pavlovich Zalygin was a Soviet writer and environmentalist, the first non-Communist Party editor-in-chief of the monthly literary magazine Novy Mir (1986–1998).